Is anyone on Methotrexate?

I just began taking methotrexate (first dose taken 30 minutes ago) to treat inflammation associated with my eye disease, chronic uveitis. I will be taking 20 mg per week, and am quite nervous about the side effects, particularly the nausea, skin rashes, and hair loss.

Who has taken MTX? What experiences and side effects have you had while on it?

Thanks in advance.

Two of my friends used this drug. You should be cautious of course and keep track of side effects and ask about alternative therapy especially if related to sarcoidosis.

Possible side effects and drug interactions

Before you begin treatment with methotrexate, you and your doctor should discuss the benefits and risks of the medicine.

Tell your doctor if you have ever had any unusual or allergic reaction to methotrexate or other related medications.

Methotrexate should never be used in pregnancy or if you are trying to conceive. Women of childbearing age MUST use a reliable method of birth control while on methotrexate. Breast-feeding is generally not recommended while on methotrexate. In addition, a period of time should pass after you finish methotrexate therapy before pregnancy is attempted. This applies to BOTH men and women.

The most common side effects are nausea, vomiting, upset stomach, loss of appetite, and irritation or ulcers of the mouth. Hair loss, rash, and/or diarrhea may also develop. Children or elderly adults may be more sensitive to methotrexate.

Side effects that are more rare include a temporary lowering of the number of white blood cells in your blood, increasing the chance of infection, a lowering of the number of platelets, affecting proper blood clotting, severe lung inflammation and liver damage.

As methotrexate may interact with certain medications, tell your doctor if you are taking any other prescription or over-the-counter medications before starting methotrexate. Specific drug interactions have been shown between methotrexate and cholestyramine, probenecid, and trimethoprim.

Patients on methotrexate therapy should not drink any alcohol because of potential liver damage.